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Thomas M Tzschentke Selected Research

Tapentadol

1/2020Population Pharmacokinetics of Tapentadol in Children from Birth to <18 Years Old.
10/2018Does 'Strong Analgesic' Equal 'Strong Opioid'? Tapentadol and the Concept of 'µ-Load'.
8/2014Opioid receptor gene expression in human neuroblastoma SH-SY5Y cells following tapentadol exposure.
5/2014The noradrenergic component in tapentadol action counteracts μ-opioid receptor-mediated adverse effects on adult neurogenesis.
12/2013Spinal-supraspinal and intrinsic μ-opioid receptor agonist-norepinephrine reuptake inhibitor (MOR-NRI) synergy of tapentadol in diabetic heat hyperalgesia in mice.
7/2012Mechanistic and functional differentiation of tapentadol and tramadol.
11/2011Antinociceptive and antihyperalgesic effects of tapentadol in animal models of inflammatory pain.
9/2011Synergistic antihypersensitive effects of pregabalin and tapentadol in a rat model of neuropathic pain.
3/2011The antinociceptive and antihyperalgesic effect of tapentadol is partially retained in OPRM1 (μ-opioid receptor) knockout mice.
9/2010Differential contribution of opioid and noradrenergic mechanisms of tapentadol in rat models of nociceptive and neuropathic pain.
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Thomas M Tzschentke Research Topics

Disease

17Pain (Aches)
01/2021 - 04/2002
9Neuralgia (Stump Neuralgia)
05/2018 - 07/2009
8Hyperalgesia
01/2021 - 02/2010
5Chronic Pain
01/2021 - 10/2007
3Diabetic Neuropathies (Diabetic Neuropathy)
05/2015 - 06/2014
3Substance-Related Disorders (Drug Abuse)
11/2014 - 12/2007
2Acute Pain
05/2022 - 01/2020
2Colitis
01/2019 - 10/2007
2Respiratory Insufficiency (Respiratory Failure)
01/2019 - 10/2018
2Arthritis (Polyarthritis)
08/2018 - 11/2011
2Hypersensitivity (Allergy)
11/2017 - 03/2011
1Neoplasms (Cancer)
01/2021
1Pancreatitis
01/2019
1Visceral Pain
01/2019
1Constipation
10/2018
1Weight Loss (Weight Reduction)
01/2018
1Substance Withdrawal Syndrome (Withdrawal Symptoms)
01/2018
1Opioid-Related Disorders (Opiate Addiction)
11/2014
1Neuroblastoma
08/2014
1Nociceptive Pain
06/2014
1Rheumatoid Arthritis
06/2014
1Bone Neoplasms (Bone Cancer)
06/2014
1Inflammation (Inflammations)
11/2011
1Cocaine-Related Disorders (Cocaine Addiction)
04/2002

Drug/Important Bio-Agent (IBA)

13TapentadolFDA Link
01/2020 - 10/2007
11Opioid Analgesics (Opioids)IBA
05/2022 - 12/2005
10Analgesics (Analgesic Drugs)IBA
01/2021 - 10/2007
10Opioid Receptors (Opioid Receptor)IBA
05/2018 - 03/2011
6NociceptinIBA
01/2021 - 04/2011
66'- fluoro- 4',9'- dihydro- N,N- dimethyl- 4- phenylspiro(cyclohexane- 1,1'(3'H)- pyrano(3,4- b)indol)- 4- amineIBA
01/2019 - 06/2014
6Morphine (MS Contin)FDA LinkGeneric
01/2018 - 02/2010
6Norepinephrine (Noradrenaline)FDA LinkGeneric
12/2013 - 09/2010
4Pharmaceutical PreparationsIBA
05/2020 - 09/2011
4Streptozocin (Streptozotocin)FDA Link
11/2017 - 02/2010
3Peptides (Polypeptides)IBA
01/2021 - 10/2014
3Opioid Peptides (Opioid Peptide)IBA
08/2018 - 10/2014
2Freund's AdjuvantIBA
08/2018 - 11/2011
2Naloxone (Narcan)FDA LinkGeneric
01/2018 - 11/2011
2Methadone (Dolophine)FDA LinkGeneric
11/2014 - 04/2002
2Buprenorphine (Subutex)FDA LinkGeneric
11/2014 - 04/2002
2Tramadol (K315)FDA LinkGeneric
07/2012 - 03/2011
2CarrageenanIBA
11/2011 - 03/2011
2Pregabalin (Lyrica)FDA Link
09/2011 - 03/2011
2Oxycodone (Oxycontin)FDA LinkGeneric
09/2011 - 03/2011
1Diphosphonates (Bisphosphonates)IBA
01/2021
1Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA
11/2020
1dibutyldichlorotinIBA
01/2019
1Drug Receptors (Drug Receptor)IBA
10/2018
1Illicit Drugs (Recreational Drugs)IBA
11/2014
14- (alpha- (4- allyl- 2,5- dimethyl- 1- piperazinyl)- 3- methoxybenzyl)- N,N- diethylbenzamideIBA
10/2014
1(trans)-Isomer 3,4- Dichloro- N- methyl- N- (2- (1- pyrrolidinyl)- cyclohexyl)- benzeneacetamideIBA
10/2014
1Opiate AlkaloidsIBA
05/2014
1Controlled SubstancesIBA
07/2012
1Yohimbine (Yocon)IBA
11/2011
1Phenol (Carbolic Acid)FDA Link
11/2011
1Formaldehyde (Formol)FDA Link
11/2011
1Drug CombinationsIBA
09/2011
1Ibuprofen (Motrin)FDA LinkGeneric
03/2011
1mu Opioid Receptors (mu Opioid Receptor)IBA
09/2010
1Ethanol (Ethyl Alcohol)IBA
12/2007
1NicotineFDA Link
12/2007
1Cocaine (Cocaine HCl)IBA
12/2007
1pyridineIBA
12/2007
1Antidepressive Agents (Antidepressants)IBA
12/2005
1Heroin (Diamorphine)IBA
04/2002

Therapy/Procedure

5Analgesia
10/2018 - 09/2010
4Ligation
05/2018 - 10/2007
2Therapeutics
11/2014 - 07/2009
1Intravenous Administration
01/2019
1Intra-Articular Injections
08/2018
1Oral Administration
06/2014
1Self Administration (Administration, Self)
12/2007